The foundations of Eczacıbaşı Sports Club were laid in 1950s with football, tennis tournaments and some other sports events held in Eczacıbaşı. These sports events were held in 1966 by Dr. Nejat Eczacıbaşı and Şakir Eczacıbaşı won a professional dimension with the establishment of Eczacıbaşı Sports Club. From 1966 to 1996, Şakir Eczacıbaşı's club presidency was served by F. Bülent Eczacıbaşı from June 6, 1996 to September 1, 1999 and from R. Faruk Eczacıbaşı since September 2, 1999.
Until today, the club has won 40 Turkish Championships in Turkish First Leagues with 13 in table tennis, eight in male basketball, three in chess, three in male and one in female volleyball. Young, Stars and Minik volleyball teams also won the Turkish championship over forty.
A Women's Volleyball team, 17 times in succession as a champion of Turkey was a record and won a total of 28 Turkish Championships. The Eczacıbaşı Women's Volleyball Team, which brought the first European Championship Cup in Turkey's volleyball with the "European Cup Galaplıs Cup" won the European Cups in 2017 for the 12th time in fourteenth final and became the European Champions League champion in 2015 , In 2015 and 2016 it became the only team to win the World Club Championship twice in a row. The team also won the Presidential Cup three times, the Turkish Cup eight times, and the Super Cup twice, twice being the second in Europe.